The maintenance mechanisms of arboviruses are investigated by studies on vertical transmission and the search for vertebrate reservoirs by identifying the origin of blood meals from collected vectors engorged in nature.
In this theme, we are studying vertical transmission and looking for vertebrate reservoirs as possible maintenance mechanisms for arboviruses. However, the vertical transmission, although demonstrated in nature and proven experimentally, occurs according to mechanisms that have not yet been elucidated. The rarity of the phenomenon and the low rates observed in nature do not allow it to be considered as the only model of maintenance. The existence of secondary cycles involving wild vertebrate reservoirs is thus mentioned. These reservoirs are usually sought using an animal capture and sampling approach for the detection of arboviruses and / or experimental estimation of the duration and level of viremia. This approach is expensive and difficult to implement given the diversity of species to be included. Ethical restrictions in animal research, and measures to protect certain species are also factors limiting such an approach. For these reasons, UEM is working, as an alternative approach, on an indirect approach to molecular characterization of blood meals from females engorged with vectors in nature in order to identify preferred hosts and potential reservoirs.
Projects and partners on this theme (logo if possible):
- Project 1. Mechanisms of emergence of dengue and Chikungunya viruses in Senegal. Funding: NIH Collaboration: IPD UAVFH, University of Texas Medical Branch (UTMB), Galveston USA, New Mexico University (US), John Hopkings University USA, Ministry of Health and Army Health Service (Senegal).
- Project 2. European West Nile collaborative research project. Funding: UE- FP7 HEALTH.2010.2.3.3-3. Partners: IPD's UAVFH and the Carlos III Health Institute (ISCIII) of Spain as part of a consortium of 14 institutions from various countries (France, Italy, Spain, Israel, Czech Republic, Senegal).