The biological, ethological and physiological behaviors of the main vectors of malaria are studied and analyzed in relation to climate and the environment to better define their vectorial capacity.
In this theme, questions relating to structuring, differentiation, speciation and adaptation to the habitat are addressed. Understanding the genetic causes and effects of speciation in sympatric vector populations is one of the essential steps for effective malaria control. In An. Gambiae, the major vector of malaria in Senegal, recent observations have highlighted the presence of S and M forms which, depending on the geographical location, show or not reproductive isolation. Thus the problem of inter and intra-form relations arises. In An. Funestus, the differences in trophic and resting behavior of populations and the recolonization of certain geographical areas have motivated the conduct of studies on the genetic structuring of its populations using cytogenetics but also the molecular tool. . This is how our programs are interested in the characterization of the spatio-temporal profiles of species or forms in relation to environmental heterogeneities through multicentric and multidisciplinary projects which call upon classical techniques of medical entomology (capture in the field , breeding, systematics, cytogenetics) coupled with more recent methods and tools in molecular biology (DNA sequencing, genotyping, validation of diagnostic tests based on PCR), functional and comparative genomics and bioinformatics. The involvement of modelers in these programs makes it possible to assess and predict the impact of these changes in vector systems on the epidemiology of transmitted diseases.
[b]Projects et partners[/b]
- INFRAVEC, Research Capacity for the Implementation of genetic control of mosquitoes. Appel d’offre EU-FP7 INFRASTRUCTURES-2008-1, Integrated Activities.
- PEPS MANGROVES, The generation of biodiversity in mangrove habitats: adaptation to salinity as a selective force driving ecological speciation in Anopheles mosquitoes.