Institut pasteur de Dakar
Accueil | Research and Public Health | Medical zoology | Entomologie | Study of virus - vector interactions

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The vector competence of naturally infected mosquitoes and the factors associated with the vector or virus involved are investigated.

Analysis of virus-vector interactions is necessary for understanding the emergence factors and mechanisms of pathogenesis. One of our priority areas of research is the study of the vectorial competence of the various arthropods found infected in nature. The vectorial competence of different vectors against various strains and / or arbovirus lines (WN, USUTU, YF, DEN, RVF, ZIK, CHIK, FVR, Mesonivirus) of major interest in public and animal health was assessed. . With the variations in skill observed, our current objective is to study the functional and mechanistic aspects of this vector skill and to identify the explanatory factors for this variability. The potential impact of the microbiota associated with vectors, the innate antiviral immune responses in vectors, the genetic variability of vectors and viruses, and insecticide resistance on vector competence and capacity are the main areas of interest.

Projects and partners

    • Project 1., Research Infrastructures for the control of vectorborne diseases (INFRAVEC 2). Financement EU-H2020. Partenaires :MIVEGEC-IRD, IPP
    • Project 2.. A Global Alliance for Zika Virus Control and Prevention (ZIKALLIANCE). Financement EU-H2020. Partenaires :MIVEGEC-IRD, IPP
    • Project 3.Diagnosis, molecular evolution and vector competence for Aedes aegypti of the ZIKA virus in Africa, Asia and the Pacific. Funding. ACIP, Partners: IP New Caledonia IP Paris, IP Cambodia, IPLaos UEM-UAVFH-IPD
    • Project 4. « Vector competence of European mosquitoes to Rift Valley fever virus ». Financemen : UE - Emida-EraNet. Partenaires: Université Edinburgh, Scotland UK, Department of Zoology University of Oxford, , IP Paris.
    • Project 5Pilot study on the role of mosquito saliva in the transmission of the Rift Valley Fever virus. Funding: ACIP. Collaboration: Institut Pasteur de Paris, IMFH, Institut Pasteur de Montevideo, Uruguay, Institut Pasteur de Dakar (UEM-UAVFH).
    • Project 6.Mechanisms of emergence of dengue and Chikungunya viruses in Senegal. Funding: NIH Collaboration: IPD (UEM-UAVFH), University of Texas Medical Branch (UTMB), Galveston USA (Scott Weaver, PI), New Mexico University (US), John Hopkings University USA, Ministry of Health and Department of Health of the armed forces (Senegal).