Institut pasteur de Dakar
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Team leader: Prof Gora DIOP; MCA Fatou THIAM; Prof Rokhaya Ndiaye DIALLO; Prof Babacar MBENGUE; Mr. Alassane THIAM; Mr. Alioune DIEYE)

The genetic factors of the parasite play a role in the development of severe forms of malaria with the existence of strains of Plasmodium falciparum that are more pathogenic than others. Asymptomatic carriage of Plasmodium falciparum is observed in more than 90% of subjects living in a holoendemic zone. Human genetic factors may play a role in the progression of the infection or its protection, or a role in the progression of the infection to severe forms. The objective is to identify genetic variants involved in the control / resistance or susceptibility to developing severe forms of malaria using transcriptomic and genomic approaches and then to search for correlations between the identified genetic markers and immune responses.