- Immunoallergic reactions in the pathophysiogenesis of malaria
Polynuclear neutrophils (PNN), representing the largest proportion of blood leukocytes, are involved in the defense mechanisms against several pathogens. Several observations reported from animal models seem to confirm their role in the pathogenesis of cerebral malaria.
The objective is to demonstrate in humans, circulating polynuclear neutrophils (PNNs) expressing FcεRI and carrying IgE on their surface on the one hand; on the other hand, to establish whether the appearance of these PNN-FcεRI / IgE is associated with the severity of the disease and / or the parasitaemia.
- [b][i]Search for biomarkers of the risk of severe forms of malaria[/i][/b]
Serious attacks of malaria would result, on the one hand, from a complex cascade of events probably including a quantitative and / or qualitative defect of the protective Ab responses, especially directed against the blood stages of the parasite and, on the other hand, a disturbance of the cytokine balance responsible for the symptoms observed. The objective is to investigate the relationships between IgG responses and hemato-parasitological and clinical data and the variation of IgG responses depending on the severity of the attacks and their outcome.