Institut pasteur de Dakar
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In the field of infectious diseases such as malaria and arboviruses, it is known that in addition to environmental factors, the genetic factors of the host also have a very important influence, especially in the fate of an infection and in the diversity of forms of manifestation of the disease. Therefore, we are working on the definition of phenotypes and the search for associated genes. The statistical approaches used (eg, variance component models) allow us to first measure the part of the variability of the phenotypes due to the genetics of the host (ie, heritability), before identifying the genes involved in a Secondly.