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Cheikh Talla 

Research Scientist specialized in biostatistics and statistics modelling

Scientist researcher, Epidemiology Unit, Pasteur Institute of Dakar, Senegal

 

Education

  • 2003: Baccalaureate,  Mathematics and Physics,  High Technical School, Maurice DelaFosse
  • 2007: Master II, Applied Mathematics, University Gaston Berger, Saint Louis, Senegal
  • 2008: DEA en Mathématiques appliquées, University Gaston Berger, Saint Louis, Senegal
  • 2017: PhD, Applied Statistics, University Gaston Berger, Saint Louis, Senegal
  • 2017: Postdoc,Biomathematics, Pasteur Institute of Dakar, Senegal
  • Since 2019: Scientist researcher, Applied Mathematics, Pasteur Institute of Dakar, Senegal

Professional Summary

I am a biostatistician currently employed at the Pasteur Institute of Dakar, Senegal as a postdoctoral fellow. I was initially trained in Senegal (Gaston Berger University and Pasteur Institute of Dakar) where I completed my Master II and PhD degrees. I am interested in statistical methods and modelling, Mixed linear modeling, hierarchical based statistical model, Bayesian methods and diagnostic tests.

Among the many tasks related to my current position at the Epidemiology Unit of Pasteur Institute, I am in charge of managing and setting-up an early warning system platform for the real time detection of any abnormal Influenza like illness event, diseases such as dengue, arboviruses and diarrhea from the syndromic sentinel sites using epidemic threshold and times series. The work experience I gathered as Statistician entitled me a solid foundation in epidemiologic and statistical methods, as well as strong interests in decision-making.

Research activities

My early works focuses on statistical methods modelling. During my PhD conducted at the Entomology Unit at Pasteur Institute of Dakar, I developed a spatio-temporal model framework using generalized linear mixed model (GLMM) to identify potential period and areas at risk and factors involved in the emergence of the RVF virus in Barkedji, Senegal. These models take into account overdispersion found in count data as well as unobserved confounding factors by including spatially structured and unstructured random effects. Findings from this project allowed to have an additional tool in the development and improvement of a monitoring system and control. This work has led to several publications as detailed below.

I also contributed through statistical modelling and biostatistics expertise to other projects in the laboratory pertaining to malaria, West Nile, and Dengue vectors.

  • Talla C, Diallo D, Dia I, Ba Y, Ndione JA, Morse A, Diop A, Diallo M. Modelling hotspots of the two dominant Rift Valley fever vectors (Aedes vexans and Culex poicilipes) in Barkédji, Sénégal. (2016). Parasites & Vectors 9: 111.
  • Ndiaye EH, Fall G, Gaye A, Bob NS, Talla C, Diagne CT, Diallo D, Ba Y, Dia I, Kohl A, Sall AA, Diallo M. Vector competence of Aedes vexans (Meigen), Culex poicilipes (Theobald) and quinquefasciatus Say from Senegal for West and East African lineages of Rift Valley fever virus. (2016). Parasites &Vectors 9(1):94.
  • Talla C, Diallo D, Dia I, Ba Y, Ndione JA, Sall AA, Morse A, Diop A, Diallo M. Statistical Modeling of the Abundance of vectors of West African Rift Valley Fever in Barkédji, Senegal. (2014). PLoS ONE 9(12).
  • Faye O, Ba Y, Faye O, Talla C, Diallo D, Chen R, Mondo M, Ba R, Macondo E, Siby T, Weaver SC, Diallo M, Sall AA. Urban Epidemic of Dengue Virus Serotype 3 Infection, Senegal, 2009. (2014). Emerging Infectious Diseases 20(3), 456.
  • Ngom EHM,Faye ND, Talla C, Ndiaye EH, Ndione JA, Faye O, Ba Y, Diallo M, Dia I. Anopheles arabiensis seasonal densities and infection rates in relation to landscape classes and climatic parameters in a Sahelian area of Senegal. (2014). BMC Infectious Diseases 2014, 14:711.
  • Diallo D, Talla C, Ba Y, Dia I, Sall AA, Diallo M. Temporal distribution and spatial pattern of abundance of the Rift Valley fever and West Nile fever vectors in Barkedji, Senegal. (2011). Journal of Vector Ecology,36(2), 426-436.

 

As part of the ongoing malaria surveillance in Dielmo and Ndiop villages coordinated by units at the Pasteur Institute in collaboration with the Institute for Research and Development, I have been recently collaborating with Dr Makhtar Niang, the principal investigator in molecular parasitology. This has led to two joint publications

  • Bei AK, Niang M, Deme AB, Daniels RF, Sarr FD, Sokhna C, Cheikh Talla, Faye J, Diagne N, Doucoure S, Mboup S, Wirth DF, Tall A, Ndiaye D, Hartl DL, Volkman SK, Toure-Balde A.(2018). Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance. J Infect Dis. Jan 30;217(4):622-627
  • Niang M, Thiam LG, Sane R, Diagne N, Cheikh Talla, Doucoure S, Faye J, Diop F, Badiane A, Diouf B, Camara D, Diene-Sarr F, Sokhna C, Richard V, Toure-Balde A. Substantial asymptomatic submicroscopic Plasmodium carriage during dry season in low transmission areas in Senegal: Implications for malaria control and elimination. (2017). PLoS One Aug 3;12(8).

This project will be an opportunity to reinforce my collaboration with Dr Niang and initiate new collaboration with others investigators involved in this project.

Activités de Santé Publique / Public Health activities

  • Since 2015 : Lecturer statistic: Master 2 Cheikh Anta Diop university
  • 2016:   Helper (INDA Hands-on NGS-Statistics, Theory and Practical session 03-14 October, 2016 Mbour Senegal)
  • Since 2015:   Lecturer data analysis with R software at the Ecole Supérieure Polytechnique de Dakar (ESP): Diploma in Conception Engineering

 Training activities

SUPERVISION OF STUDENTS (supervision of Master)

  • 03/15 – 11/15: Master 2 in Public Health for Marion Dollat, CNAM / Pasteur, France
  • 04/17 -11/17:  Master 2 in Public health for Florent Arinal, CNAM / Pasteur, France
  • 2020            :  Master 2 Institut Africain des Sciences Mathématiques/Mbour
  • 2020            :  Master 2 Institut Africain des Sciences Mathématiques/Mbour
  • 2020            :  Master 2 Institut Africain des Sciences Mathématiques/Mbour
  • 2021            :  Master 1 Institut National des Sciences Appliquées (INSA)/ Toulouse

 Main publications

FAO meeting: Participation to discussions with experts for “Rift Valley Fever Progressive Control Stakeholders Coordination Meeting” 22 to 24 July 2014, Dakar (Senegal).

  • Cheikh Talla, Diawo Diallo, Ibrahima Dia, Yamar Ba, Jacques-André Ndione Andy Morse, Aliou Diop, Mawlouth Diallo. Symposium of the Institut Pasteur International Network, Paris-France, September 10-13, 2014.Poster
  • Cheikh Talla, Diawo Diallo, Ibrahima Dia, Jacques-André Ndione, Mawlouth Diallo. Summer School on climate impacts modelling for developing countries: Waters, Agriculture and Health. (The Abdus Salam International Center for Theoretical Physics) Trieste-Italy September 2011. Oral Communication

Liste des publications

  1. Taieb F, Mbaye KD, Tall B, Lakhe NA, Talla C, Thioub D, Ndoye AM, Ka D, Gaye A, Cissé Diallo VM, Dia N, Ba PS, Cissé M, Diop M, Diagne CT, Fortes L, Diop M, Fall NM, Sarr FD, Diatta M, Barry MA, Badiane AS, Seck A, Dubrous P, Faye O, Vigan-Womas I, Loucoubar C, Sall AA, Seydi M. Hydroxychloroquine and Azithromycin Treatment of Hospitalized Patients Infected with SARS-CoV-2 in Senegal from March to October 2020. J Clin Med. 2021 Jun 30;10(13):2954. doi:10.3390/jcm10132954. PMID: 34209237; PMCID: PMC8269162.
  2. Niang M, Sandfort M, Mbodj AF, Diouf B, Talla C, Faye J, Sane R, Thiam LG, Thiam A, Badiane A, Vigan-Womas I, Diagne N, Diene Sarr F, Mueller I, Sokhna C, White M, Toure-Balde A. Fine-scale spatio-temporal mapping of asymptomatic and clinical P. falciparum infections: epidemiological evidence for targeted malaria elimination interventions. Clin Infect Dis. 2021 Mar 2:ciab161. doi: 10.1093/cid/ciab161. Epub ahead of print. PMID: 33677477.
  3. Gildas Boris H, Idrissa D, Marie Louise S, C Talla, Aliou BM, Fatoumata DS, Rebecca G, Raymond B, Diamilatou T, Vincent R, Oumar F, Abdoulaye S, Muriel V. Identification of Pathogens Potentially Associated with Non-Malarial Fever in Children: A Pilot Study in Peri-Urban Dakar, Senegal. Am J Trop Med Hyg. 2021 Feb 8;104(4):1335–41. doi: 10.4269/ajtmh.19-0963. Epub ahead of print. PMID: 33556036; PMCID: PMC8045601.
  4. Barry MA, Arinal F, Talla C, Hedible BG, Sarr FD, Ba IO, Diop B, Dia N, Vray M. Performance of case definitions and clinical predictors for influenza surveillance among patients followed in a rural cohort in Senegal. BMC Infect Dis. 2021 Jan 7;21(1):31. doi: 10.1186/s12879-020-05724-x. PMID: 33413174; PMCID: PMC7790019.
  5. Talla C, Pierre-Audigier C., Alame-Emane, A. K., Audigier, B., Grall, N., Ruimy, R., ... & Armand-Lefevre, L. (2020). Tuberculosis trends in a hot-spot region in Paris, France. The International Journal of Tuberculosis and Lung Disease, 24(4), 428-435.
  6. Gaye A, Diagne MM, Ndiaye EH, Dior Ndione MH, Faye M, Talla C, Fall G, Ba Y, Diallo D, Dia I, Handschumacher P, Faye O, Sall AA, Diallo M. Vector competence of anthropophilic mosquitoes for a new mesonivirus in Senegal. Emerg Microbes Infect. 2020 Feb 28;9(1):496-504. doi: 10.1080/22221751.2020.1730710. PMID: 32106784; PMCID: PMC7054948.
  7. Cheikh Talla, Dollat M, Sokhna C, Diene Sarr F, Trape JF, Richard V. Measuring malaria morbidity in an area of seasonal transmission: Pyrogenic parasitemia thresholds based on a 20-year follow-up study. PLoS One. 2019 Jun 27;14(6).
  1. Beye NF, Kane C, Ayessou N, Kebe CMF, Talla Cheikh, Diop CM, Sène A. Modelling the dehydration kinetics of four onion varieties in an oven and a solar greenhouse. Heliyon. 2019 Sep 14;5(9)
  2. Makhtar N., Talla C, Nafissatou D, Fatoutama D.S, Cheikh S. Po 8419 spatio-temporal mapping of asymptomatic and clinical malaria infections reveals foci of malaria transmission for targeted control interventions. BMJ Global Health 2019;4: A35.
  1. Matheus S, Talla C, Labeau B, de Laval F, Briolant S, Berthelot L, Vray M, Rousset D. Performance of 2 Commercial Serologic Tests for Diagnosing Zika Virus Infection. Emerg Infect Dis. 2019 Jun;25(6):1153-1160.
  1. Beye, N., Ayessou, N., Kane, C., Mbaye, M., Talla C., Sene, A., & Diop, C. Study of four onion varieties drying kinetics in an oven and a solar greenhouse. J. Food Res. (2019), 8(3), p59.
  1. Sane R, Talla C, Diouf B, Sarr FD, Diagne N, Faye J, Badiane A, Sembène PM, Sokhna C, Toure-Balde A, Niang M. Low genetic diversity and complexity of submicroscopic Plasmodium falciparum infections among febrile patients in low transmission areas in Senegal. PLoS One. 2019 Apr 25;14(4).
  1. Gaye A, Wang E, Vasilakis N, Guzman H, Diallo D, Cheikh Talla, Ba Y, Dia I, Weaver SC, Diallo M. Potential for sylvatic and urban Aedes mosquitoes from Senegal to transmit the new emerging dengue serotypes 1, 3 and 4 in West Africa, PLoS Negl Trop Dis. 2019 Feb 13;13(2): e0007043, 2019 Feb.
  1. Niang MN, Barry MA, Cheikh Talla, Mbengue A, Sarr FD, Ba IO, Hedible BG, Ndoye B, Vray M, Dia N; 4S Network Group. Estimation of the burden of flu-association influenza-like illness visits on total clinic visits through the sentinel influenza monitoring system in Senegal during the 2013-2015 influenzas seasons. Epidemiol Infect (2018) Dec ;146(16):2049-2055.
  1. Beye, N. F., Kane, C., Ayessou, N. C., Cheikh Talla., Sene, A., & Diop, C. M. Influence of Variety and Maturity Level on Natural Convective Heat Drying of Four Onion Varieties Grown in Senegal. Food and Nutrition Sciences, (2018). 9(08), 997.
  1. Bei AK, Niang M, Deme AB, Daniels RF, Sarr FD, Sokhna C, Cheikh Talla, Faye J, Diagne N, Doucoure S, Mboup S, Wirth DF, Tall A, Ndiaye D, Hartl DL, Volkman SK, Toure-Balde A. (2018). Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance. J Infect Dis. Jan 30;(2017) (4):622-627
  1. Niang M, Thiam LG, Sane R, Diagne N, Cheikh Talla, Doucoure S, Faye J, Diop F, Badiane A, Diouf B, Camara D, Diene-Sarr F, Sokhna C, Richard V, Toure-Balde A. Substantial asymptomatic submicroscopic Plasmodium carriage during dry season in low transmission areas in Senegal: Implications for malaria control and elimination. (2017). PLoS One Aug 3;12(8).
  1. Cheikh Talla, Diawo Diallo, Ibrahima Dia, Yamar Ba, Jacques-André Ndione Andy Morse, Aliou Diop, Mawlouth Diallo. Modelling hotspots of the two dominant Rift Valley fever vectors (Aedes vexans and Culex poicilipes) in Barkédji, Sénégal. (2016). Parasites & Vectors 9: 111.
  1. El Hadji Ndiaye, Gamou Fall, Alioune Gaye, Ndeye Sakha Bob, Cheikh Talla, Cheikh Tidiane Diagne, Diawo Diallo, Yamar Ba, Ibrahima Dia, Alain Kohl, Amadou Alpha Sall, Mawlouth Diallo. Vector competence of Aedes vexans (Meigen), Culex poicilipes (Theobald) and Cx. quinquefasciatus Say from Senegal for West and East African lineages of Rift Valley fever virus. (2016). Parasites &Vectors 9(1):94.
  1. Cheikh Talla, Diawo Diallo, Ibrahima Dia, Yamar Ba, Jacques-André Ndione, Amadou Alpha Sall, Andy Morse, Aliou Diop, Mawlouth Diallo. Statistical Modeling of the Abundance of vectors of West African Rift Valley Fever in Barkédji, Senegal. (2014). PLoS One 9(12).
  1. Ousmane Faye, Yamar Ba, Oumar Faye, Cheikh Talla, Diawo Diallo, Rubing Chen, , Mireille Mondo, Rouguiétou Ba, , Rouguiétou Ba, Edgard Macondo, Tidiane Siby, D, Scott C. Weaver, Mawlouth Diallo, Amadou Alpha Sall. Urban Epidemic of Dengue Virus Serotype 3 Infection, Senegal, 2009. (2014). Emerging Infectious Diseases 20(3), 456.
  1. El Hadji Malick Ngom, Ndèye Diango Faye, Cheikh Talla, El Hadji Ndiaye, Jacques-André Ndione, Ousmane Faye, Yamar Ba, Mawlouth Diallo, Ibrahima Dia. Anopheles arabiensis seasonal densities and infection rates in relation to landscape classes and climatic parameters in a Sahelian area of Senegal. (2014). BMC Infectious Diseases (2014), 14:711.
  1. Diawo Diallo, Cheikh Talla, Yamar Ba, Ibrahima Dia, Amadou Alpha Sall, and Mawlouth Diallo. Temporal distribution and spatial pattern of abundance of the Rift Valley fever and West Nile fever vectors in Barkedji, Senegal. (2011). Journal of Vector Ecology, 36(2), 426-436.

Talla Cheikh

Chercheur spécialisé en biostatistique et modélisation statistique
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