Institut pasteur de Dakar
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Dr Gamou FALL

Research Associate

Head of the Yellow fever Regional Reference Lab

WHO Collaborating Center for arbovirus

and hemorrhagic fever viruses

Virology department-Institut Pasteur de Dakar

Tel : +221-338399200

Fax : +221-338399210

E-mail: gamou.fall@pasteur.sn

 

Education

2018: Yellow Fever MAC-HD ELISA kit Training, CDC Fort Collins, Colorado, USA

2017: Trainings on Next Generation sequencing using Illumina Miseq at Institut Pasteur de Dakar (sponsored by USAMRIID), SENEGAL

2017: Zika and Yellow fever laboratory diagnostics workshop (Sponsored by CDC), UVRI, Entebbe, Uganda

2016: Training on Genomics (Sponsored by African Centre of Excellence for Genomics of Infectious Diseases), Sabeti Lab at Harvard University, USA

2015: Point of care Diagnostics for Ebola virus, Pasteur Institute Dakar, SENEGAL

2014: Workshop on Risk communication training related to public health emergency, Wolmar, Mauritius

2012: Workshop on Genomics and molecular biology applications for pathogen detection and characterization, Pasteur Institute Tunis, TUNISIA 

2010: Advanced Course of Fundamental Virology, Pasteur Institute Paris, FRANCE (with honors)

2005-2009: Ph.D. on Parasitology, Montpellier 2 University, FRANCE (with honors)

 

Professional Summary

January 2020 to now : Research Associate, Virology Pole, Institut Pasteur de Dakar, Senegal

January 2014-December 2019 : Research Assistant, Virology Pole, Institut Pasteur de Dakar, Senegal

October 2009 - December 2013 : Post-Doc, Arbovirus and hemorrhagic fever virus unit, Institut Pasteur de Dakar, Senegal

 

Research activities

My research activities are mainly focused on the analysis of vector-virus-host interactions. This topic studies the vector competence of mosquitoes for arboviruses as well as the virus and mosquito factors that could impact the transmission and pathogenesis in the vertebrate host. Over few years, I develop real expertise in this field from the descriptive and mechanistic point of view by using West Nile, Rift Valley fever and Usutu virus as models. Indeed, through different collaborative research projects, I have been able to conduct studies on the assessment of mosquito vector competence as well as roles of viral genetic diversity, mosquito RNA interference and saliva in the transmission and infection outcome in the vertebrate hosts.

Beyond this topic, I am also involved in research projects on the evaluation of fractional doses of the yellow fever vaccine. Indeed, in the context when the demand for yellow fever vaccines is greater than the supply, validation of the use of fractional doses of the vaccine could be an excellent strategy for the elimination of yellow fever epidemics.

I am also involved in other research activities including the evaluation and validation of diagnostic tools and the strengthening of arbovirus surveillance.

Currently, I have several research grants from different funders including Organization for Women in Science for the Developing World (OWSD) and the National Institutes of Health (NIH).

 

 

 

Public Health activities

I am the Head of the yellow fever regional reference laboratory in the context of the WHO network of yellow fever laboratories. The roles of this regional reference laboratory are to confirm results from National laboratories (NLs) in the West African region, to provide NLs with technical support, especially during outbreaks and to conduct yellow fever risk assessment on request of WHO and the countries. In addition I have mastered field deployment for public health purposes such as outbreak investigation and control at the national and international level.

Then I am involved in different activities :

 

  • Diagnostic of Yellow fever and other arbovirus and hemorrhagic fever viruses tested in the differential diagnostic: coordination of molecular and serological testing of human samples, result validation and reporting.
  • Coordination of arbovirus isolation and identification tests (cell culture, RT-PCR, sequencing…) from mosquito pools collected in the field.
  • Deployment by WHO and GOARN as laboratory expert for technical support to countries during outbreaks
  • Hepatitis E outbreak in Niger, 18 to 24 June 2017 (WHO)
  • Dengue outbreak in Burkina Faso: 18 November to 8 December 2016 (WHO)
  • Rift Valley fever outbreak in Niger: 12 to 30 October 2016 (GOARN)
  • Yellow fever outbreak in Angola: 4 March to 14 April 2016, and 30 May to 12 June 2016 (WHO)
  • Consultancies: Yellow fever laboratory capacity on-site assessment for possible Gavi investment, organized by Gavi between September and December 2018 (The Gambia, Guinea, Guinea-Bissau and Niger)
  • Member of the laboratory technical working group of the EYE (Eliminate Yellow fever Epidemics) strategy and I participate to monthly meetings.

 

  • Training activities

I supervise different Master and PhD students in the framework of their training at the University.

I am also involved in the organization of workshops and training activities. These workshops are organized through research collaborations or under request of WHO, WAHO for Strengthening Laboratory Capacities in Africa as well as at international level.  

 

  • Main publications
  • Fall G, Diallo D, Soumaila H, Ndiaye EH, Lagare A, Sadio BD, Ndione MHD, Wiley M, Dia M, Diop M, Ba A, Sidikou F, Ngoy BB, Faye O, Testa J, Loucoubar C, Sall AA, Diallo M, Faye O. First Detection of the West Nile Virus Koutango Lineage in Sandflies in Niger. 2021 Feb 24;10(3):257. PMID: 33668365
  • Aitana Juan-Giner, Derick Kimathi, Kyra H Grantz, Mainga Hamaluba, Patrick Kazooba, Patricia Njuguna, Gamou Fall, Moussa Dia, Ndeye S Bob, Thomas P Monath, Alan D Barrett, Joachim Hombach, Edgar M Mulogo, Immaculate Ampeire, Henry K Karanja, Dan Nyehangane, Juliet Mwanga-Amumpaire, Derek A T Cummings, Philip Bejon, George M Warimwe, Rebecca F Grais. Immunogenicity and safety of fractional doses of yellow fever vaccines: a randomised, double-blind, non-inferiority trial. Lancet. 2021 Jan 9;397(10269):119-127. PMID: 33422245
  • Marie Henriette Dior Ndione, El Hadji Ndiaye, Marème Sèye Thiam, Manfred Weidmann, Martin Faye, Yamar Ba, Jessica Benkaroun, Oumar Faye, Cheikh Loucoubar, Pape Mbacké Sembène, Mawlouth Diallo, Amadou Alpha Sall, Ousmane Faye, Gamou Fall. Impact of Genetic Diversity on Biological Characteristics of Usutu Virus Strains in Africa. Virus Res. Nov 2019 ; 273, 197753.  PMID: 31521764
  • Lagare A, Fall G, Ibrahim A, Ousmane S, Sadio B, Abdoulaye M, Alhassane A, Mahaman AE, Issaka B, Sidikou F, Zaneidou M, Bienvenue B, Djingarey Mamoudou H, Bailo Diallo A, Kadadé G, Testa J, Boubacar Mainassara H, Faye O. First occurrence of Rift Valley fever outbreak in Niger, 2016. Vet Med Sci. 2019 Feb;5(1):70-78. PMID: 30411868
  • Fall G, Di Paola N, Faye M, Dia M, Freire CCM, Loucoubar C, Zanotto PMA, Faye O, Sall AA. Biological and phylogenetic characteristics of West African lineages of West Nile virus. PLoS Negl Trop Dis. 2017 Nov 8;11(11):e0006078. doi: 10.1371/journal.pntd.0006078. [Epub ahead of print] PMID: 29117195. PMID: 29117195
  • Fall G, Faye Oum, Fanny B, Magassouba N’F, Koivogui L, Faye Ous, Sall AA. Ebola virus outbreak in West Africa, 2014-2016 : roles of Institut Pasteur de Dakar laboratory. Review. African Journal of Medical Biology / Revue Africaine de Biologie Médicale - Année 2017 ; Tome 2 (N°4) - Août 2017
  • Ka D, Fall G (co-first author), Diallo VC, Faye O, Fortes LD, Faye O, Bah EI, Diallo KM, Balique F, Ndour CT, Seydi M, Sall AA. Ebola Virus Imported from Guinea to Senegal, 2014. Emerg Infect Dis. 2017 Jun;23(6):1026-1028. doi: 10.3201/eid2306.161092. PMID: 28518019
  • Simon-Loriere E, Faye O, Prot M, Casademont I, Fall G, Fernandez-Garcia MD, Diagne MM, Kipela JM, Fall IS, Holmes EC, Sakuntabhai A, Sall AA. Autochthonous Japanese Encephalitis with Yellow Fever Coinfection in Africa. N Engl J Med. 2017 Apr 13; 376(15):1483-1485. PMID: 28402771
  • Fall G, Faye M, Weidmann M, Kaiser M, Dupressoir A, Ndiaye EH, Ba Y, Diallo M, Faye O, Sall AA. Real-Time RT-PCR Assays for Detection and Genotyping of West Nile Virus Lineages Circulating in Africa. Vector Borne Zoonotic Dis. 2016 Oct 6 ; 16(12):781-789. PMID: 27710313
  • Simon-Loriere E, Faye O, Faye O, Koivogui L, Magassouba N, Keita S, Thiberge JM, Diancourt L, Bouchier C, Vandenbogaert M, Caro V, Fall G, Buchmann JP, Matranga CB, Sabeti PC, Manuguerra JC, Holmes EC, Sall AA. Distinct lineages of Ebola virus in Guinea during the 2014 West African epidemic. Nature. 2015 Jun 24 ; 6;524(7563):102-4. PMID: 26106863
  • Gamou Fall, Mawlouth Diallo, Cheikh Loucoubar, Ousmane Faye, Amadou Alpha Sall. “Vector Competence of Culex neavei and Culex quinquefasciatus (Diptera: Culicidae) for lineages 1, 2 Koutango and a putative new lineage of West Nile Virus from Africa”. American Journal of Tropical Medecine and Hygiene. 2014; 90(4): 747–754. PMID: 27710313

 

Complete list of publications

https://pubmed.ncbi.nlm.nih.gov/?term=gamou+fall

 

Dr Gamou Fall

Researcher